GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6734238 | 1 | rs6734238 | chr2:113841030 | IL1B | chr2:113587337-113594356:- | -0.17 | -3.4 | 0.000722 | C-reactive protein levels or total cholesterol levels (pleiotropy);C-reactive protein;White blood cell count;Fibrinogen;C-reactive protein levels;Fibrinogen levels |
| THCA | cis | rs4663866 | 1 | rs6734408 | chr2:239137481 | LOC151174 | chr2:239133754-239140318:- | 0.56 | 5.85 | 8.99E-9 | Irritable bowel syndrome |
| THCA | cis | rs673604 | 1 | rs673604 | chr1:35687815 | ZMYM4 | chr1:35734568-35887544:+ | -0.14 | -3.77 | 0.000185 | Endometrial cancer |
| THCA | cis | rs35123781 | 1 | rs673632 | chr5:139057237 | DNAJC18 | chr5:138747381-138775139:- | 0.16 | 3.58 | 0.000383 | Schizophrenia |
| THCA | cis | rs5743030 | 1 | rs6736360 | chr2:190748749 | ASNSD1 | chr2:190526125-190535556:+ | -0.55 | -5.72 | 1.9E-8 | Subcutaneous adipose tissue |
| THCA | cis | rs9309473 | 1 | rs6736866 | chr2:73661986 | ALMS1P | chr2:73872046-73912692:+ | 0.76 | 11.68 | 6.48E-28 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6736866 | chr2:73661986 | NAT8 | chr2:73867850-73869537:- | 0.42 | 6.45 | 2.72E-10 | Metabolite levels |
| THCA | cis | rs13014235 | 1 | rs6737085 | chr2:202221441 | ALS2CR12 | chr2:202153148-202222101:- | -0.36 | -7.19 | 2.54E-12 | Basal cell carcinoma |
| THCA | cis | rs13014235 | 1 | rs6737085 | chr2:202221441 | PPIL3 | chr2:201735680-201753999:- | -0.24 | -4.92 | 1.19E-6 | Basal cell carcinoma |
| THCA | cis | rs237743 | 1 | rs67375757 | chr20:47916295 | DDX27 | chr20:47835832-47860612:+ | 0.27 | 4.94 | 1.08E-6 | Height |
| THCA | cis | rs6547741 | 1 | rs6737921 | chr2:27839107 | FNDC4 | chr2:27714751-27718126:- | -0.14 | -3.41 | 0.000717 | Oral cavity cancer |
| THCA | cis | rs67385638 | 1 | rs67385638 | chr11:5290370 | HBG2 | chr11:5269502-5667011:- | 0.25 | 3.88 | 0.000121 | Hemoglobin levels |
| THCA | cis | rs7582720 | 1 | rs6738618 | chr2:203749439 | ALS2CR8 | chr2:203776978-203851060:+ | -0.29 | -5.93 | 5.93E-9 | Coronary artery disease or large artery stroke;Coronary artery disease or ischemic stroke |
| THCA | cis | rs7582720 | 1 | rs6738618 | chr2:203749439 | ICA1L | chr2:203637873-203736371:- | 0.25 | 4.18 | 3.49E-5 | Coronary artery disease or large artery stroke;Coronary artery disease or ischemic stroke |
| THCA | cis | rs4665809 | 1 | rs6739061 | chr2:26256147 | GPR113 | chr2:26531041-26569685:- | -0.41 | -6.51 | 1.92E-10 | Gut microbiome composition (summer) |